SAR-20347 (Standard)

• Description:

  SAR-20347 (Standard) is the analytical standard of SAR-20347 (HY-100895) . This product is intended for research and analytical applications. SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively.

• Target:

  JAK; Reference Standards

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=C(NC2=CC=C(C(N3CCOCC3)=O)C=C2)OC(C4=C(F)C=CC=C4Cl)=N1)N

• Molecular Formula:

  C21H18ClFN4O4

• Molecular Weight:

  444.84

• References & Citations:

  [1]Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193 (7) :3278-87.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [1450881-55-6]