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AS1517499 (Standard)

CAT: 0804-HY-100614RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100614RSize:1 Each
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Description
AS1517499 (Standard) is the analytical standard of AS1517499. This product is intended for research and analytical applications. AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
CAS Number
919486-40-1
Target
Reference Standards; STAT
Related Pathways
JAK/STAT Signaling; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cancer
Smiles
O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.86
References & Citations
[1]Nagashima S, et al. Synthesis and evaluation of 2-{[2- (4-hydroxyphenyl) -ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15 (2) :1044-55.|[2]Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41 (5) :516-24.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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