AS1517499

CAT: 0421-82693-3Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0421-82693-3Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

STAT6 (signal transducer and activator of transcription 6) is a member of the STAT family of proteins which activate gene expression by relaying signals from cytokines that bind to their receptors on the cell surface to the nucleus. STAT6 is mainly activated by IL-4 (interleukin-4) and IL-13, via phosphorylation by JAKs (Janus kinases) . Once phosphorylated, STAT6 forms a homodimer that translocate to the nucleus and binds to DNA via the DNA-binding domain, activating gene transcription. STAT6 signaling is involved in T-helper type 2 (Th2) cell development and differentiation, macrophage activation, and it impacts the levels of CD20 on the surface of B lymphocytes. Gene fusions products of STAT6 with NGFI-A-binding protein 2 (NAB2) are responsible for fibrous tumors. Dysfunction of the STAT6 pathway leads to allergic reactions (asthma, atopic dermatitis, food allergies) and cancer (Hodgkin, central nervous system and follicular lymphoma) . STAT6 can serve as a diagnostic and prognostic tool. Inhibitors have been shown to reduce acute inflammation in animal models, and future developments may lead to new therapeutical tools for STAT6 related pathologies.

Description

AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50of 21 nM.1

CAS Number

919486-40-1

Purity

≥ 90%

Format

Solid.

Solubility

Soluble in DMSO up to 35 mg/mL.

Molecular Formula

C20H20ClN5O2

Shipping Conditions

Room Temperature

Storage Conditions

Powder-20°C3 years4°C2 yearsIn solvent-80°C2 years-20°C1 year

Calculated Molecular Weight

397.86 Da

Alternative Products

Catalog	Name
BA6403-10	AS1517499
HY-100614R	AS1517499 (Standard)

AS1517499

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