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Rilmenidine (Standard)

CAT: 0804-HY-100490RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100490RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rilmenidine (Standard) is the analytical standard of Rilmenidine. This product is intended for research and analytical applications. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
CAS Number
54187-04-1
UNSPSC
12352005
Target
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor; Reference Standards
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cancer; Cardiovascular Disease
Smiles
C1(NC(C2CC2)C3CC3)=NCCO1
Molecular Formula
C10H16N2O
Molecular Weight
180.25
References & Citations
[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13 (6 Pt 2) :106S-111S.|[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.|[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19 (11) :2144-2153.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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