Rilmenidine

• Description :

  Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/rilmenidine.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  C1(NC(C2CC2)C3CC3)=NCCO1

• Molecular Formula :

  C10H16N2O

• Molecular Weight :

  180.25

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13 (6 Pt 2) :106S-111S.|[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.|[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19 (11) :2144-2153.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [54187-04-1]