Rilmenidine

CAT: 0804-HY-100490-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100490-01Size:5 mg
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Description
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
CAS Number
[54187-04-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rilmenidine.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C1(NC(C2CC2)C3CC3)=NCCO1
Molecular Formula
C10H16N2O
Molecular Weight
180.25
Precautions
H315, H319, H320
References & Citations
[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13 (6 Pt 2) :106S-111S.|[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.|[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19 (11) :2144-2153.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched

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