Nevanimibe hydrochloride (Standard)

• Description :

  Nevanimibe hydrochloride (Standard) is the analytical standard of Nevanimibe hydrochloride. This product is intended for research and analytical applications. Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].

• Product Name Alternative :

  PD-132301 hydrochloride (Standard) ; ATR101 hydrochloride (Standard)

• UNSPSC :

  12352005

• Target :

  Acyltransferase; Apoptosis; Reference Standards

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl

• Molecular Formula :

  C27H40ClN3O

• Molecular Weight :

  458.08

• References & Citations :

  [1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157 (5) :1775-88.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [133825-81-7]