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Nevanimibe hydrochloride (Standard)

CAT: 0804-HY-100399AR-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100399AR-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nevanimibe hydrochloride (Standard) is the analytical standard of Nevanimibe hydrochloride. This product is intended for research and analytical applications. Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].
CAS Number
133825-81-7
Product Name Alternative
PD-132301 hydrochloride (Standard) ; ATR101 hydrochloride (Standard)
UNSPSC
12352005
Target
Acyltransferase; Apoptosis; Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl
Molecular Formula
C27H40ClN3O
Molecular Weight
458.08
References & Citations
[1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157 (5) :1775-88.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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