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Nevanimibe hydrochloride

CAT: 0804-HY-100399A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100399A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].
CAS Number
133825-81-7
Product Name Alternative
PD-132301 hydrochloride; ATR101 hydrochloride
UNSPSC
12352005
Target
Acyltransferase; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nevanimibe_hydrochloride.html
Purity
99.49
Solubility
DMSO : 41.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCC1(C2=CC=C(N(C)C)C=C2)CCCC1)NC3=C(C(C)C)C=CC=C3C(C)C.[H]Cl
Molecular Formula
C27H40ClN3O
Molecular Weight
458.08
References & Citations
[1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157 (5) :1775-88.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ACAT1; ACAT2
Citation 01
Mol Cell Endocrinol. 2024 Dec 1:594:112385.|Structure. 2021 Dec 2;29 (12) :1410-1418.e4.|Cell Rep. 2022 Nov 29;41 (9) :111724.

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