Nevanimibe hydrochloride

• Description:

  Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].

• Product Name Alternative:

  PD-132301 hydrochloride; ATR101 hydrochloride

• UNSPSC:

  12352005

• Target:

  Acyltransferase; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Nevanimibe_hydrochloride.html

• Purity:

  99.49

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NCC1 (C2=CC=C (N (C) C) C=C2) CCCC1) NC3=C (C (C) C) C=CC=C3C (C) C.[H]Cl

• Molecular Formula:

  C27H40ClN3O

• Molecular Weight:

  458.08

• References & Citations:

  [1]LaPensee CR, et al. ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs. Endocrinology. 2016 May;157 (5) :1775-88.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  ACAT1; ACAT2

• Citation 01:

  Mol Cell Endocrinol. 2024 Dec 1:594:112385.|Structure. 2021 Dec 2;29 (12) :1410-1418.e4.|Cell Rep. 2022 Nov 29;41 (9) :111724.

• CAS Number:

  133825-81-7