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Rabbit Polyclonal Antibody to RFFL

CAT: 1725-P08690-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P08690-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.
Product Name Alternative
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN
Swiss Prot
Q8WZ73
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human RFFL
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
RFFL