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Rabbit Polyclonal Antibody to MAP2K3

CAT: 1725-P07512-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P07512-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Product Name Alternative
MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2
Swiss Prot
P46734
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Fusion protein of human MAP2K3
Clonality
Polyclonal
Applications
WB, IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
MAP2K3
Bands Size
39 kDa