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Rabbit Polyclonal Antibody to MAPK8IP1

CAT: 1725-P04985-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P04985-01Size:50 µL
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Description
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8) . This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Product Name Alternative
IB1; JIP1; JIP-1; PRKM8IP
Swiss Prot
Q9UQF2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human MAPK8IP1
Clonality
Polyclonal
Applications
WB
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
MAPK8IP1
Bands Size
78 kDa

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