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Rabbit Polyclonal Antibody to CLASP2

CAT: 1725-P09518-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P09518-01Size:50 µL
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Description
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921) . Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) . Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950) . This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514) . Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Swiss Prot
O75122
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human CLASP2
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CLASP2