NH2-NODAGA

• UNSPSC Description:

  NH2-NODAGA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA can react with diethyl squarate in 0.5M phosphate buffer (room temperature, 2 h, pH 7-7.5) to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.

• Target Antigen:

  PSMA; Radionuclide-Drug Conjugates (RDCs)

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/nh2-nodaga.html

• Smiles:

  O=C(CN1CCN(CCN(C(CCC(NCCN)=O)C(O)=O)CC1)CC(O)=O)O

• Molecular Weight:

  417.46

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1630114-57-6