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NODAGA-LM3 (TFA)

CAT: 0804-HY-P5362ASize: 1 EachDry Ice: NoHazardous: No
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Description
NODAGA-LM3 TFA can be labeled by 68Ga for PET imaging. 68Ga-NODAGA-LM3 TFA is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas. NODAGA-LM3 TFA can be labeled with [68Ga] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) [1][2][3].
UNSPSC
12352209
Target
Radionuclide-Drug Conjugates (RDCs) ; Somatostatin Receptor
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nodaga-lm3-tfa.html
Purity
96.35
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]1CC2=CC=C(NC(N)=O)C=C2)[C@H](CC3=CC=C(O)C=C3)NC([C@H](NC([C@H](CC4=CC=C(Cl)C=C4)NC(CCC(C(O)=O)N5CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O)=O)CSSC[C@@H](C(N[C@H](CC6=CC=C(O)C=C6)C(N)=O)=O)NC([C@]([H])([C@@H](C)O)NC([C@H](CCCCN)NC1=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]
Molecular Formula
C68H90ClN15O19S2.xC2HF3O2
Molecular Weight
1521.11 (free acid)
References & Citations
[1]Fani M, et al. PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference. J Nucl Med. 2011 Jul;52 (7) :1110-8. |[2]Zhu W, et al. A Prospective, Randomized, Double-Blind Study to Evaluate the Safety, Biodistribution, and Dosimetry of 68Ga-NODAGA-LM3 and 68Ga-DOTA-LM3 in Patients with Well-Differentiated Neuroendocrine Tumors. J Nucl Med. 2021 Oct;62 (10) :1398-1405.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 2
Isoform
SSTR2

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