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GPI-1046

CAT: 0804-HY-124619-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124619-01Size:5 mg
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Description
GPI-1046 is an orally active, antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core) . GPI-1046 improves human immunodeficiency virus (HIV) -associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity[1][2][3].
CAS Number
186452-09-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EAAT; HIV
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gpi-1046.html
Purity
99.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCCCC1=CC=CN=C1)[C@H]2N(C(C(C(C)(C)CC)=O)=O)CCC2
Molecular Formula
C20H28N2O4
Molecular Weight
360.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35.|[2]Höke A, et al. GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry. J Peripher Nerv Syst. 2009 Mar;14 (1) :27-35.|[3]Ganel R, et al. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol Dis. 2006 Mar;21 (3) :556-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GlyT1

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BA1909-5.1GPI-1046
A13015-50GPI-1046 50mg
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A13015-5GPI-1046 5mg
A13015-2GPI-1046 2mg
A13015-1GPI-1046 1mg
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