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Human IL-6 Protein

CAT: 0749-PRP1012-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1012-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
Description
Human IL-6 protein, expressed in E. coli
Product Name Alternative
BSF2; HGF; HSF; IFNB2; IL-6; Interleukin-6; Interleukin-6; IL-6
Gene ID
3569
Accession Number
P05231
Tag
IL-6
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Measured in a cell proliferation assay using TF -1. The ED50 for this effect is typically 2.25 ng/mL. The specific activity of recombinant Human IL6 is approximately >4.44 x 105 IU/mg
Molecular Weight
20.6 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 0.1 EU per μg of the protein by the LAL method
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Human IL-6 protein should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant human IL-6 consists of 187 amino acids and migrates with an apparent molecular mass of 20.6 kDa as estimated in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile 150mM NaCl 20mM Tris , pH 7.4.
Applications Notes
Human
Other Product Names
BSF2; HGF; HSF; IFNB2; IL-6; Interleukin-6; Interleukin-6; IL-6
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL-6 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Preparation
E. coli
Accession Number URL
http://www.uniprot.org/uniprot/P05231
AA Sequence
Amino acid sequence derived from mature form of human IL-6 (NP_000591.1) (Val 30-Met 212) was expressed, with an initial Met at the N-terminus.

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