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Alloc-Val-Ala-pAB

CAT: 0931-TYD-02095-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TYD-02095-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1343407-91-9
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Alloc-Val-Ala-PAB is a cleavable peptide linker employed in the synthesis of antibody-drug conjugates (ADC) . The Val-Ala sequence is specifically cleaved by cathepsin B. The Alloc group remains stable when treated with piperidine and TFA, yet it can be easily removed under mild conditions via palladium-catalyzed allyl transfer.
Smiles
N(C([C@@H](NC([C@@H](NC(OCC=C)=O)[C@@H](C)C)=O)C)=O)C1=CC=C(CO)C=C1
Molecular Formula
C19H27N3O5
Molecular Weight
377.435
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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