Alloc-Val-Ala-OH

CAT: 0931-TYD-01870-01Size: 10 mgDry Ice: NoHazardous: No

CAT#:0931-TYD-01870-01Size:10 mg

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AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

330970-70-2

Bioactivity

Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) serves as a building block in the synthesis of Tesirine, which is a clinical antibody-drug conjugate (ADC) featuring a pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala sequence is cleaved specifically by cathepsin B. The Alloc group is stable towards piperidine and TFA, yet can be easily removed under mild conditions via palladium-catalyzed allyl transfer.

Smiles

[C@H](C(N[C@H](C(O)=O)C)=O)(NC(OCC=C)=O)C(C)C

Molecular Formula

C12H20N2O5

Molecular Weight

272.298

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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HY-W076556-01	Alloc-Val-Ala-OH
HY-W071967-01	Alloc-Val-Ala-pAB
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260678-01	Ala-Val-OH
292002-01	Val-Ala-OH
RM-F131628-01	Fmoc-β-Ala-Val-Oh
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Alloc-Val-Ala-OH

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