C14-490

CAT: 0931-TYD-01884-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TYD-01884-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2639634-82-3
Target
Liposome
Related Pathways
Metabolism
Bioactivity
C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs) . These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F (ab’) 2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs) .
Smiles
OC(CN(CCN1CCN(CC1)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC
Molecular Formula
C86H177N5O7
Molecular Weight
1393.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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