C14-490

• Description :

  C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs) . C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F (ab’) 2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs) [1].

• UNSPSC :

  12352211

• Target :

  Liposome

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Others

• Smiles :

  OC(CCCCCCCCCCCC)CN(CC(CN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)OCC)CCN1CCN(CC(CN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)OCC)CC1

• Molecular Formula :

  C86H177N5O7

• Molecular Weight :

  1393.35

• References & Citations :

  [1]Rohan Palanki, et al. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2024 Aug 6;121 (32) :e2400783121.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported

• CAS Number :

  [2639634-82-3]