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Eps8 peptide 327

CAT: 0931-TP3778-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3778-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1988684-26-9
Target
Apoptosis, EGFR, Complement System, Interleukin, TNF, IFNAR
Related Pathways
JAK/STAT signaling, Immunology/Inflammation, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from the Eps8 protein. It exhibits potent antitumor activity and significant cytotoxicity. Eps8 peptide 327 effectively inhibits cancer cell proliferation, induces apoptosis, and disrupts the EGFR signaling pathway by inhibiting the expression of downstream signals such as IL-2, TNF-α, and IFN-γ, as well as impeding the Eps8/EGFR interaction. It significantly suppresses tumor growth in HT-29 xenograft models.
Smiles
[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)CCCCN)=O)CCC(N)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(O)=O)N)=O)=O)CC(C)C)=O)CC(O)=O)=O)CS)=O
Molecular Formula
C56H77N11O15S
Molecular Weight
1176.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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