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MACTIDE-V

CAT: 0931-TP3253-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3253-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain, YAP
Related Pathways
Stem Cells, Chromatin/Epigenetic
Bioactivity
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. This compound delivers Verteporfin to CD206+ tumor-associated macrophages (TAM), thereby inhibiting the YAP/TAZ signaling pathway. It facilitates YAP exclusion from the nucleus, induces TAM polarization toward an anti-tumor phenotype, enhances phagocytosis and antigen presentation, and promotes T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models.
Molecular Formula
C109H156N22O27S2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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