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MACTIDE-V

CAT: 0804-HY-P10947Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10947Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin to CD206+ tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models[1].
UNSPSC
12352209
Target
Epigenetic Reader Domain; YAP
Related Pathways
Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)\NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=C\C3=C4CCC(NCCCCCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N7[C@@H](CCC7)C(NCC(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)NC8=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N9[C@@H](CCC9)C(N%10[C@@H](CCC%10)C(N[C@H]8[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O
Molecular Formula
C109H156N22O27S2
Molecular Weight
2270.67
References & Citations
[1]Lepland A, et al. Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer. Adv Sci (Weinh) . 2025 Mar;12 (10) :e2410288.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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