WKYMVM-NH2

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells through the FPRL1 and FPRL2 receptors, with EC50 values of 2 nM for HL-60-FPRL1 cells and 80 nM for HL-60-FPRL2 cells. It also induces chemotaxis in HL-60 cells stably expressing FPRL2, with optimal migration observed at concentrations ranging from 10 to 50 nM. Additionally, WKYMVM-NH2 stimulates neutrophils to produce superoxide with an EC50 of 75 nM. It is applicable in research focused on inflammatory diseases.

• Smiles:

  C ([C@@H] (C (N[C@H] (C (N[C@@H] (CC1=CC=C (O) C=C1) C (N[C@H] (C (N[C@H] (C (N[C@@H] (CCSC) C (N) =O) =O) [C@@H] (C) C) =O) CCSC) =O) =O) CCCCN) =O) N) C=2C=3C (NC2) =CC=CC3

• Molecular Formula:

  C41H61N9O7S2

• Molecular Weight:

  856.109

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  187986-11-4