FSLLRY-NH2

• Target:

  Protease-activated Receptor

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.

• Smiles:

  [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)N)=O)CO)=O)CC(C)C)=O)CC(C)C)=O)(C(N[C@@H](CC2=CC=C(O)C=C2)C(N)=O)=O)CCCNC(=N)N

• Molecular Formula:

  C39H60N10O8

• Molecular Weight:

  796.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  245329-02-6