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TAT-N15

CAT: 0931-TP3106-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3106-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2415370-74-8
Target
NF-κB, Akt, STAT, Interleukin
Related Pathways
JAK/STAT signaling, Cytoskeletal Signaling, Immunology/Inflammation, PI3K/Akt/mTOR signaling, NF-κB, Stem Cells
Bioactivity
TAT-N15, a p55PIK inhibitor, demonstrates significant anti-inflammatory and neuroprotective effects. It effectively suppresses the activation of IL-6, IL-8, Akt, and NF-κB pathways, along with the phosphorylation of STAT3 and the protein expression of NF-κB. TAT-N15 is applicable for research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke through its inhibition of Akt, STAT3, and NF-κB pathways.
Smiles
C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(O)=O)CCC4)CC(O)=O)=O)CCSC)=O)CCC(O)=O)=O)[C@H](CC)C)=O)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CO)=O)(=O)[C@H]5N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC6=CC=C(O)C=C6)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCSC)=O)CCSC)=O)CCC5
Molecular Formula
C155H250N48O40S3
Molecular Weight
3522.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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