PIC1 PA

CAT: 0931-MF-0126731-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0126731-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1356469-36-7
Target
Complement System
Related Pathways
Immunology/Inflammation
Bioactivity
PIC1 PA, a peptide consisting of 15 amino acids, serves as an effective analog of PIC1 that inhibits complement activation mediated by the classical pathway. Functionally, PIC1 PA interferes with the interaction between the C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q/MBL. It specifically binds to the CLR of C1q, with an average equilibrium dissociation constant (KD) of 33.3 nM when binding purified C1q.
Smiles
C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)CCC(O)=O)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)C)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC(N)=O)=O)CS)=O)CS)=O)[C@H](CC)C)=O)CCC1
Molecular Formula
C71H123N19O21S2
Molecular Weight
1642.98
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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