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Cyclic L27-11

CAT: 0931-TP2754-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-TP2754-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1221423-80-8
Target
Antibacterial
Related Pathways
Microbiology/Virology
Bioactivity
Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS) . This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.
Smiles
C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N6[C@@](C(=O)N7C(C(=O)N[C@@]([C@@H](C)O)(C(=O)N3)[H])(CCC7)[H])(CCC6)[H]
Molecular Formula
C87H141N27O15
Molecular Weight
1805.22
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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