Cyclic L27-11

• Target :

  Antibacterial

• Related Pathways :

  Microbiology/Virology

• Bioactivity :

  Cyclic L27-11 is a cyclic peptide analog antibiotic that exhibits potent antimicrobial activity against specific bacteria, particularly Pseudomonas sp. It is highly effective against Pseudomonas aeruginosa, demonstrating nanomolar-level antibacterial activity. The mechanism of action for Cyclic L27-11 involves interfering with the function of the bacterial outer membrane protein LptD, inhibiting the normal transport of lipopolysaccharide (LPS) . This inhibition leads to the accumulation of membrane-like substances within the bacterial cell, adversely affecting bacterial survival. Consequently, Cyclic L27-11 is a promising candidate for antimicrobial agent development.

• Smiles :

  C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N6[C@@](C(=O)N7C(C(=O)N[C@@]([C@@H](C)O)(C(=O)N3)[H])(CCC7)[H])(CCC6)[H]

• Molecular Formula :

  C87H141N27O15

• Molecular Weight :

  1805.22

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1221423-80-8