Cyclic ADP-ribose

• Target:

  Endogenous Metabolite|||Calcium Channel|||TRP/TRPV Channel

• Related Pathways:

  Metabolism|||Membrane transporter/Ion channel

• Bioactivity:

  Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx via the opening of TRPM2 channels.

• Smiles:

  O[C@H]1[C@@]2(N3C4=C(N=C3)C(=N)N(C=N4)[C@@]5(O[C@@]([C@@H](O)[C@H]5O)(COP(=O)(O)OP(=O)(O)OC[C@@](O2)([C@H]1O)[H])[H])[H])[H]

• Molecular Formula:

  C15H21N5O13P2

• Molecular Weight:

  541.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  119340-53-3