Chaetoglobosin E

• Target :

  Ferroptosis

• Related Pathways :

  Apoptosis

• Bioactivity :

  Chaetoglobosin E is a ferroptosis inducer exhibiting significant cytotoxicity against the human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 ?M and 7.47 ?M, respectively. It induces ferroptosis by downregulating GPX4 expression in A549 cells, leading to increased intracellular levels of Fe2+ (iron ions) and the lipid peroxidation product malondialdehyde (MDA), resulting in mitochondrial shrinkage and reduced or absent cristae. Chaetoglobosin E is applicable in cancer research.

• Smiles :

  O=C1[C@]23[C@]([C@H](CC=4C=5C(NC4)=CC=CC5)N1)(C(C)=C(C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)/C=C(\C)/C(=O)[C@@H](O)CCC3=O)[H])[H]

• Molecular Formula :

  C32H38N2O5

• Molecular Weight :

  530.654

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  55945-74-9