Lipid 114

• Target :

  Liposome

• Related Pathways :

  Metabolism

• Bioactivity :

  Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1? can reduce IL-1? expression in macrophages. Additionally, these LNPs lower IL-1? expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C