ROC-0929

• Target :

  Others|||Phospholipase

• Related Pathways :

  Others|||Metabolism

• Bioactivity :

  ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s), targeting hGX with an IC50 of 80 nM. It efficiently inhibits the phosphorylation of ERK1/2 and p-38. sPLA2s, part of the disulfide-rich, Ca2+-dependent enzyme family, catalyze the hydrolysis of glycero-phospholipids at the sn-2 position, releasing a fatty acid and a lysophospholipid. ROC-0929 is promising for research on inflammation-related diseases.

• Smiles :

  CC(C)Cc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1

• Molecular Formula :

  C30H31N3O6S

• Molecular Weight :

  561.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1048660-43-0