EGFR-IN-119

CAT: 0931-T89479-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T89479-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Kras, p38 MAPK, Reactive Oxygen Species, Ras, EGFR

Related Pathways

Angiogenesis, JAK/STAT signaling, MAPK, Tyrosine Kinase/Adaptors, NF-κB, Metabolism, Immunology/Inflammation, GPCR/G Protein

Bioactivity

EGFR-IN-119 (Compound 5l) functions as an inhibitor of EGFR with an IC50 of 84.3 nM. It exhibits cytotoxic effects in A549 lung cancer cells with an IC50 of 1.34 μM. Additionally, EGFR-IN-119 downregulates the expression of EGFR, KRAS, and MAP2K genes. It displays antioxidative activity by decreasing reactive oxygen species (ROS) and hyperpolarizing mitochondrial membrane potential.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-163880	EGFR-IN-119
77-071	TER-119 Antibody [TER-119]
77-082	TER-119 Antibody [TER-119] (APC)
77-081	TER-119 Antibody [TER-119] (PE)
BA3722-5.1	TAS-119
HY-P991066-01	ARGX-119
BT162778-01	TWS 119
MBS131030-01	TWS-119
GTR19195031-01	CK-119
GTR19193751	LNC-119

EGFR-IN-119

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