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YGT-31

CAT: 0931-T89287-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T89287-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2835447-74-8
Bioactivity
YGT-31 is a PPARγ modulator with an IC50 of 1.72 μM and a Ki of 0.62 μM. It diminishes blood glucose levels and enhances insulin sensitivity in a type 2 diabetes model in db/db mice by inhibiting CDK5-mediated phosphorylation of PPARγ-Ser273. Additionally, YGT-31 exhibits anti-steatotic effects in a mouse model of non-alcoholic fatty liver disease (NAFLD) .
Smiles
O=C1C=C(OC=2C=C(OCC(=O)NCC3=CC=C(C=C3)C(F)(F)F)C=C(O)C12)C=4C=CC=CC4
Molecular Formula
C25H18F3NO5
Molecular Weight
469.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(5-hydroxy-4-oxo-2-phenylchromen-7-yl)oxy-N-[[4-(trifluoromethyl)phenyl]methyl]acetamide
CAS Number2835447-74-8
PubChem CID172419458
IUPAC Name2-(5-hydroxy-4-oxo-2-phenylchromen-7-yl)oxy-N-[[4-(trifluoromethyl)phenyl]methyl]acetamide
Molecular FormulaC25H18F3NO5
Molecular Weight469.4
XLogP4.1
Topological Polar Surface Area84.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity756
SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)OCC(=O)NCC4=CC=C(C=C4)C(F)(F)F)O
InChI
InChI=1S/C25H18F3NO5/c26-25(27,28)17-8-6-15(7-9-17)13-29-23(32)14-33-18-10-19(30)24-20(31)12-21(34-22(24)11-18)16-4-2-1-3-5-16/h1-12,30H,13-14H2,(H,29,32)
InChIKey
LJLGNPSPXNZOCN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(5-hydroxy-4-oxo-2-phenylchromen-7-yl)oxy-N-[[4-(trifluoromethyl)phenyl]methyl]acetamide
CAS: 2835447-74-8
CID: 172419458
Formula: C25H18F3NO5
MW: 469.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.4
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass469.11370716
Monoisotopic Mass469.11370716
Topological Polar Surface Area84.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity756
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19238058-01YGT-31
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MBS6483271-01Interleukin 31 (IL-31) (APC)
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