MTI-31

• Target:

  MTOR

• Related Pathways:

  PI3K/Akt/mTOR signaling

• Purity:

  0.9997

• Bioactivity:

  MTI-31 (LXI-15029) is a potent, orally active, and highly selective inhibitor of mTORC1 and mTORC2, exhibiting a Kd of 0.20 nM for mTOR and >5,000-fold selectivity over PIK3CA, PIK3CB, and PIK3G in binding assays, with an IC50 of 39 nM for mTOR in a LANCE assay of mTOR substrate phosphorylation with 100 ?M ATP [1].

• Smiles:

  CNC(=O)c1cccc(c1)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1C2CCC1COC2

• Molecular Formula:

  C26H30N6O3

• Molecular Weight:

  474.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1567915-38-1