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MTI-31

CAT: 0931-T35343-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T35343-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1567915-38-1
Target
MTOR
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9997
Bioactivity
MTI-31 (LXI-15029) is a potent, orally active, and highly selective inhibitor of mTORC1 and mTORC2, exhibiting a Kd of 0.20 nM for mTOR and >5,000-fold selectivity over PIK3CA, PIK3CB, and PIK3G in binding assays, with an IC50 of 39 nM for mTOR in a LANCE assay of mTOR substrate phosphorylation with 100 μM ATP [1].
Smiles
CNC(=O)c1cccc(c1)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1C2CCC1COC2
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C