PI3Kα-IN-21

CAT: 0931-T89205-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T89205-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, PI3K

Related Pathways

Apoptosis, PI3K/Akt/mTOR signaling

Bioactivity

PI3Kα-IN-21 (compound 8) is a selective inhibitor of PI3Kα, demonstrating greater selectivity over PI3Kβ, PI3Kγ, and PI3Kδ by factors of 10.41, 16.99, and 37.53 respectively (IC50: 96.89/568.24/397.48 nM) . This compound inhibits cancer cell activity, proliferation, and migration while inducing mitochondrial apoptosis through the PI3K/Akt/mTOR pathway. Additionally, PI3Kα-IN-21 has shown in vivo antitumor efficacy in a mouse model of non-small cell lung cancer.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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PI3Kα-IN-21

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