Nampt-IN-12

CAT: 0931-MF-0148279-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0148279-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2427862-70-0
Target
NAMPT|||Others
Related Pathways
Others|||Metabolism
Bioactivity
Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.
Smiles
O=C(NC=1SC=CC1)C=2C=NC=CC2
Molecular Formula
C10H8N2OS
Molecular Weight
204.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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