BSJ-5-63

• Target:

  CDK|||PROTACs

• Related Pathways:

  Cell Cycle/Checkpoint|||PROTAC

• Bioactivity:

  BSJ-5-63 is an effective degrader of CDK12, CDK7, and CDK9. It reduces the protein expression of CDK12, CDK7, CDK9, RNAPII, and Cyclin K, and also decreases the mRNA expression of BRCA1 and BRCA2. BSJ-5-63 exhibits anticancer activity and holds potential for prostate cancer research.

• Smiles:

  C([C@@H](NC(CCCCCCCCCCN1C[C@H](NC=2N=C(NC3=C(S(C(C)C)(=O)=O)C=CC=C3)C(Cl)=CN2)CCC1)=O)[C@](C)(C)C)(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4

• Molecular Formula:

  C52H74ClN9O6S2

• Molecular Weight:

  1020.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2519823-37-9