BSJ-4-116

• Target:

  PROTACs|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||PROTAC

• Purity:

  0.9909

• Bioactivity:

  BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly (adenylation) .

• Smiles:

  O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCN4C[C@H](NC=5N=C(NC6=C(S(C(C)C)(=O)=O)C=CC=C6)C(Cl)=CN5)CCC4)=O

• Molecular Formula:

  C40H49ClN8O8S

• Molecular Weight:

  837.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2519823-34-6