DLC-50

CAT: 0931-T88516-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T88516-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2928537-98-6
Target
HDAC|||Apoptosis|||PARP
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair
Bioactivity
DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 ?M, 2.7 ?M, and 2.41 ?M respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.
Smiles
O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=S)SCCCCCCC(=O)NO)CC4
Molecular Formula
C28H32FN5O4S2
Molecular Weight
585.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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