KL-50

• CAS Number :

  1161826-19-2

• Target :

  DNA/RNA Synthesis|||Others

• Related Pathways :

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others

• Bioactivity :

  KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.

• Smiles :

  O=C(N)C=1N=CN2C(=O)N(N=NC12)CCF

• Molecular Formula :

  C7H7FN6O2

• Molecular Weight :

  226.17

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C