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KIF18A-IN-10

CAT: 0931-T88253-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88253-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3034542-28-1
Target
Microtubule Associated, Kinesin
Related Pathways
Cytoskeletal Signaling
Bioactivity
KIF18A-IN-10 (Compound 24) is a potent inhibitor of KIF18A with an IC50 value of 3.8 nM. It exhibits anticancer activity with IC50 values below 100 nM in OVCAR3 and MDA-MB-157 cells.
Smiles
O=C(NC1=NC2=C(C=NN2C3CC(F)(F)C3)C=C1)C4=CC=C(C=C4N5CCC6(CC5)CC6)NS(=O)(=O)CCO
Molecular Formula
C26H30F2N6O4S
Molecular Weight
560.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Kif18A-IN-10
CAS Number3034542-28-1
PubChem CID171714348
IUPAC Name2-(6-azaspiro[2.5]octan-6-yl)-N-[1-(3,3-difluorocyclobutyl)pyrazolo[5,4-b]pyridin-6-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
Molecular FormulaC26H30F2N6O4S
Molecular Weight560.6
XLogP3.5
Topological Polar Surface Area138
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Heavy Atom Count39
Formal Charge0
Complexity1010
SMILES
C1CC12CCN(CC2)C3=C(C=CC(=C3)NS(=O)(=O)CCO)C(=O)NC4=NC5=C(C=C4)C=NN5C6CC(C6)(F)F
InChI
InChI=1S/C26H30F2N6O4S/c27-26(28)14-19(15-26)34-23-17(16-29-34)1-4-22(30-23)31-24(36)20-3-2-18(32-39(37,38)12-11-35)13-21(20)33-9-7-25(5-6-25)8-10-33/h1-4,13,16,19,32,35H,5-12,14-15H2,(H,30,31,36)
InChIKey
JKYUWOONBCWYMP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Kif18A-IN-10
CAS: 3034542-28-1
CID: 171714348
Formula: C26H30F2N6O4S
MW: 560.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight560.6
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count8
Exact Mass560.20173096
Monoisotopic Mass560.20173096
Topological Polar Surface Area138 Ų
Heavy Atom Count39
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-162532KIF18A-IN-10
MBS6002075-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A)
524734-01KIF18A
MBS6313229-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (FITC)
MBS6313227-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (APC)
MBS6313226-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (AP)
037435-PEKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (PE)
MBS6313228-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (Biotin)
037435-APKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (AP) discontinued
037435-BiotinKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (Biotin) discontinued

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