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HIF-2α-IN-10

CAT: 0931-T88180-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88180-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3034532-74-3
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
HIF-2α-IN-10 (17) acts as a potent HIF-2α inhibitor, exhibiting an IC 50 value of 0.05 μM.
Smiles
C(C(CC1CC(F)(F)C1)=O)(=O)N2[C@]3([C@H](O)C(F)(F)C2)CC(F)(F)CC3
Molecular Formula
C15H17F6NO3
Molecular Weight
373.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Hif-2|A-IN-10
CAS Number3034532-74-3
PubChem CID171714328
IUPAC Name3-(3,3-difluorocyclobutyl)-1-[(4S,5S)-3,3,8,8-tetrafluoro-4-hydroxy-1-azaspiro[4.4]nonan-1-yl]propane-1,2-dione
Molecular FormulaC15H17F6NO3
Molecular Weight373.29
XLogP2.2
Topological Polar Surface Area57.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity602
SMILES
C1CC(C[C@]12[C@@H](C(CN2C(=O)C(=O)CC3CC(C3)(F)F)(F)F)O)(F)F
InChI
InChI=1S/C15H17F6NO3/c16-13(17)2-1-12(6-13)11(25)15(20,21)7-22(12)10(24)9(23)3-8-4-14(18,19)5-8/h8,11,25H,1-7H2/t11-,12-/m0/s1
InChIKey
MMJPOKGOXKDWAL-RYUDHWBXSA-N
Chemical Structure
2D Structure
2D structure of Hif-2|A-IN-10
CAS: 3034532-74-3
CID: 171714328
Formula: C15H17F6NO3
MW: 373.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.29
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count3
Exact Mass373.11126238
Monoisotopic Mass373.11126238
Topological Polar Surface Area57.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity602
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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