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HIF-2α-IN-15

CAT: 0931-T88074-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T88074-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033981-70-0
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
HIF-2α-IN-15 (35) acts as a HIF-2α inhibitor and exhibits an inhibitory concentration (IC 50) of 0.41 μM.
Smiles
C(=O)(N1[C@@]2([C@@H](O)C(F)(F)C1)CC(F)(F)CC2)C=3N=C(Cl)C=CC3
Molecular Formula
C14H13ClF4N2O2
Molecular Weight
352.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Hif-2|A-IN-15
CAS Number3033981-70-0
PubChem CID171714333
IUPAC Name(6-chloro-2-pyridinyl)-[(4R,5R)-3,3,8,8-tetrafluoro-4-hydroxy-1-azaspiro[4.4]nonan-1-yl]methanone
Molecular FormulaC14H13ClF4N2O2
Molecular Weight352.71
XLogP2.8
Topological Polar Surface Area53.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Heavy Atom Count23
Formal Charge0
Complexity507
SMILES
C1CC(C[C@@]12[C@H](C(CN2C(=O)C3=NC(=CC=C3)Cl)(F)F)O)(F)F
InChI
InChI=1S/C14H13ClF4N2O2/c15-9-3-1-2-8(20-9)10(22)21-7-14(18,19)11(23)12(21)4-5-13(16,17)6-12/h1-3,11,23H,4-7H2/t11-,12-/m1/s1
InChIKey
RQZGCVPASNEBIG-VXGBXAGGSA-N
Chemical Structure
2D Structure
2D structure of Hif-2|A-IN-15
CAS: 3033981-70-0
CID: 171714333
Formula: C14H13ClF4N2O2
MW: 352.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.71
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass352.0601680
Monoisotopic Mass352.0601680
Topological Polar Surface Area53.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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HY-163602HIF-2α-IN-15
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