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BODIPY-Cyclopamine

CAT: 0931-T88053-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88053-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
334658-24-1
Target
Others, Smo
Related Pathways
Others, Stem Cells
Bioactivity
BODIPY-Cyclopamine is a fluorescent ligand for the Smoothened (SMO) receptor. SMO activation, which is regulated by Patch protein, is linked to tumorigenesis when excessively activated. Using NanoBRET technology, sensitive detection of the resonance energy transfer between SMO and BODIPY-Cyclopamine can be achieved, facilitating high-throughput screening and kinetic analysis. Additionally, studying the binding sites of BODIPY-Cyclopamine on SMO can aid in discovering SMO-targeted drugs.
Smiles
C[C@H]1[C@]2(C(C)=C3[C@@](CC2)([C@]4([C@](C3)([C@]5(C)C(=CC4)C[C@@H](O)CC5)[H])[H])[H])O[C@]6([C@]1(N(CCNC(CCCCCNC(CCC=7[N-]8C(=CC7)C=C9[N]([B+3]8([F-])[F-])=C(C)C=C9C)=O)=O)C[C@@H](C)C6)[H])[H]
Molecular Formula
C49H70BF2N5O4
Molecular Weight
841.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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