RegisterLogin

KAAD-Cyclopamine

CAT: 0931-T35558Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T35558Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
306387-90-6
Target
Others|||Smo
Related Pathways
Others|||Stem Cells
Bioactivity
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated oncogene 1 (Gli1) and cytosolic MMP-9, pERK1, and pERK2 proteins in a dose-dependent manner. Cyclopamine-KAAD also increases TRAIL-mediated cell death in NCH82 and NCH89 human glioblastoma cultures and upregulates expression of the death receptors DR4 and DR5 in LN229 and U251 glioma cells.
Smiles
C[C@H]1[C@]2(C(C)=C3[C@@](CC2)([C@]4([C@](C3)([C@]5(C)C(=CC4)CC(=O)CC5)[H])[H])[H])O[C@]6([C@]1(N(CCNC(CCCCCNC(CCC7=CC=CC=C7)=O)=O)C[C@@H](C)C6)[H])[H]
Molecular Formula
C44H63N3O4
Molecular Weight
697.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T2825-01Cyclopamine
T88053-01BODIPY-Cyclopamine
T39854-01Cycloposine
TCL-01116-01DSPE-PEG5000-KAA
T70293-01KAA-276 HCl
TCL-01189-01DSPE-PEG1000-KAA
TCL-01321-01DSPE-PEG3400-KAA
T70294-01KAA-276 free base
TCL-01165-01DSPE-PEG2000-KAA

Alternative Products

CatalogName
sc-221448Cyclopamine-KAAD
HY-100535-01KAAD-Cyclopamine
K02923-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)
MBS6058421-013-Keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl Cyclopamine (KAAD-Cyclopamine)
217304Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldihydrocinnamoyl cyclopamine, Shh Signaling Antagonist II)
MBS3604524-01Cyclopamine

Popular Products