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DACN (Tos2,6-OH)

CAT: 0931-T87926-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87926-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2109751-74-6
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
DACN (Tos2,6-OH) serves as a potent click chemistry reagent featuring an Azide group and a distinctively bent alkyne moiety. This structure enhances its reactivity for cycloaddition reactions compared to nonbent acyclic alkynes, especially evident in cyclononyne alkynes which exhibit substantially higher reactivity. The bent configuration adds both electronic and steric effects that intensify the reactivity, facilitating strain-promoted azide-alkyne cycloaddition (SPAAC) . SPAAC with cycloalkynes is commonly utilized for dependable molecular conjugation across various fields. Furthermore, DACN (Tos2,6-OH) can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), coupling efficiently with molecules that contain Azide groups. Compared to cyclooctynes, DACNs demonstrate superior thermal and chemical stabilities while maintaining similar click reactivity [1]. Nitrogens within the compound provide versatile linking sites for numerous functional units.
Smiles
S(=O)(=O)(C1=CC=C(C)C=C1)N2CC(O)CN(S(=O)(=O)C3=CC=C(C)C=C3)CC#CC2
Molecular Formula
C21H24N2O5S2
Molecular Weight
448.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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