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TREM2-IN-1

CAT: 0931-T87562Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T87562Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2000236-36-0
Target
Others, Apoptosis
Related Pathways
Others, Apoptosis
Purity
0.9856
Bioactivity
TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.
Smiles
[O-](C(CCC(O[C@@H]1O[C@]2([C@]34[C@]([C@H]1C)(CC[C@@H](C)[C@@]3(CC[C@](C)(O2)OO4)[H])[H])[H])=O)=O)[Pt+4]56([O-]C(CCC(O[C@@H]7O[C@]8([C@]9%10[C@]([C@H]7C)(CC[C@@H](C)[C@@]9(CC[C@](C)(O8)OO%10)[H])[H])[H])=O)=O)([NH2]C%11C([NH2]5)CCCC%11)[O-]C(=O)C(=O)[O-]6
Molecular Formula
C46H68N2O20Pt
Molecular Weight
1164.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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