Pacritinib citrate

• Target:

  JAK|||FLT

• Related Pathways:

  JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic

• Bioactivity:

  Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM) . It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM) . This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].

• Smiles:

  OC(CC(O)(C(O)=O)CC(O)=O)=O.N1(CCCC1)CCOc2c3cc(Nc4nc(c5cc(COC/C=C/COC3)ccc5)ccn4)cc2

• Molecular Formula:

  C34H40N4O10

• Molecular Weight:

  664.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1228923-42-9