Pacritinib citrate

• Target :

  JAK|||FLT

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic

• Bioactivity :

  Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM) . It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM) . This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].

• Smiles :

  OC(CC(O)(C(O)=O)CC(O)=O)=O.N1(CCCC1)CCOc2c3cc(Nc4nc(c5cc(COC/C=C/COC3)ccc5)ccn4)cc2

• Molecular Formula :

  C34H40N4O10

• Molecular Weight :

  664.7

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1228923-42-9