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Pacritinib citrate

CAT: 0931-T87094-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T87094-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1228923-42-9
Target
JAK, FLT
Related Pathways
JAK/STAT signaling, Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM) . It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM) . This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].
Smiles
OC(CC(O)(C(O)=O)CC(O)=O)=O.N1(CCCC1)CCOc2c3cc(Nc4nc(c5cc(COC/C=C/COC3)ccc5)ccn4)cc2
Molecular Formula
C34H40N4O10
Molecular Weight
664.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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