Pacritinib

CAT: 0804-HY-16379-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16379-01Size:5 mg
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Description
Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM) . Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM) .
CAS Number
[937272-79-2]
Product Name Alternative
SB1518
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FLT3; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pacritinib.html
Purity
99.93
Solubility
0.1 M HCl : 2 mg/mL (ultrasonic) |1 M HCl : ≥ 100 mg/mL|DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1
Molecular Formula
C28H32N4O3
Molecular Weight
472.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Hart S, et al. SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies. Leukemia. 2011 Nov;25 (11) :1751-9.|[2]Hart S, et al. Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia. Blood Cancer J. 2011 Nov;1 (11) :e44.|[3]William AD, et al. Discovery of the macrocycle 11- (2-pyrrolidin-1-yl-ethoxy) -14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1 (2,6) .1 (8,12) ]heptacosa-1 (25),2 (26),3,5,8,10,12 (27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JA
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
JAK1; JAK2; JAK3; Tyk2

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