JGB-1-155

• CAS Number :

  3011930-28-9

• Target :

  NAMPT

• Related Pathways :

  Metabolism

• Bioactivity :

  JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 ?M. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNF?-induced reactive oxygen species (ROS) in HT-22 cells [1].

• Smiles :

  C(CN(C(=O)C1=CC=CO1)CC2=CC=C(N(C)C)C=C2)C3(C(C)C)CC(C)(C)OCC3

• Molecular Formula :

  C26H38N2O3

• Molecular Weight :

  426.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C